DOI: https://doi.org/10.29363/nanoge.obe.2022.012
Publication date: 14th January 2022
In vitro models of biological systems are essential for our understanding of biological systems. In many cases where animal models have failed to translate to useful data for human diseases, physiologically relevant in vitro models can bridge the gap. Many difficulties exist in interfacing complex, 3D cell biology models with technology adapted for monitoring function. Polymeric electroactive materials and devices can bridge the gap between hard inflexible materials used for physical transducers and soft, compliant biological tissues. An additional advantage of these electronic materials is their flexibility for processing and fabrication in a wide range of formats. In this presentation, I will discuss our recent progress in pushing conducting polymer devices, to 3D, to simultaneously host and monitor complex multi-cellular models of tissues and organs. Building on our previous work that showcased a bioelectronic model of the human intestine, we are now incorporating elements of the microbiome and the immune system as well as the enteric nervous system. Coupling this model with our model of the neuro-vascular unit (including blood brain barrier) currently in progress, will bring us to our goal of a physiologically representative in vitro model of the gut-brain-microbiome axis.
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