DOI: https://doi.org/10.29363/nanoge.amamed.2022.004
Publication date: 22nd April 2022
Advancements in the use of nanoparticles for biomedical applications have clearly shown their potential for the preparation of improved imaging and drug-delivery systems. However, only a few successfully translate into clinical practice, because, a common “barrier” preventing nanoparticles from delivering efficiently their payload to the target site after administration, is related to the nanoparticle uptake by macrophages. We have recently reported disulfide-bridged organosilica nanoparticles with cage-like morphology, and assessed in detail their bioaccumulation in vivo. [1] The fate of intravenously injected 20 nm nanocages was investigated in both healthy and tumor bearing mice. Interestingly, the nanoparticles exclusively co-localize with hepatic sinusoidal endothelial cells (LSECs), while avoiding Kupffer-cell uptake (less than 6%), in both physiological and pathological condition. Our findings suggest that organosilica nanocages hold the potential to be used as nanotools for LSECs modulation, potentially impacting key biological processes such as tumor cell extravasation and hepatic immunity to invading metastatic cells or a tolerogenic state in intrahepatic immune cells in autoimmune diseases.
Such nanocages are also able to stabilize out of equilibrium species and transport them inside cells were they can be released and evolve towards the equilibrium state. [2]
Finally the combination of nanoparticles with injectable hydrogels can be used for tumor resection or tissue regeneration. [3-4]. Indeed, injectable nanocomposite hydrogel able to form in situ a tissue, are an innovative material that can be employed for the treatment of esophageal fistulas. [4]
The material, easily injectable with an endoscopic needle, is formed in a time compatible with the surgical procedure and has final mechanical properties suitable for cell proliferation. The in vivo experiments (porcine model) on esophageal-cutaneous fistulas, showed improved healing in the animals treated with the hydrogel compared with the control group.
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