Synthesis, characterization and application of magnetically hybrid nanostructured systems
Loretta L. del Mercato a
a CNR NANOTEC Institute of Nanotechnology, Via Monteroni, 73100 Lecce, Italy
Proceedings of Advanced materials and devices for nanomedicine (AMA4MED)
VALÈNCIA, Spain, 2022 May 3rd - 4th
Organizers: Claudia Tortiglione and María Moros
Invited Speaker, Loretta L. del Mercato, presentation 019
Publication date: 22nd April 2022

Herein, the synthesis and application of nanostructured materials will be described with a special focus on the properties they could offer for medical applications. Examples will be given in which (i) multilayered magnetic nanobeads are explored for the delivery of peptides molecules triggered by intracellular proteases,[1] (ii) extracellular matrix-like magnetic nanofibers are realized as manipulative hyperthermia material and switchable drug release platforms (Figure 1).[2]

Figure 1. Magnetically hybrid nanostructured systems.

[1] Quarta, A.; Rodio, M.; Cassani, M.; Gigli, G.; Pellegrino, T.; del Mercato, L.L. Multilayered Magnetic Nanobeads for the Delivery of Peptides Molecules Triggered by Intracellular Proteases. ACS Applied Materials and Interfaces, 2017, 9, 35095-35104.

[2] Serio, F.; Silvestri, N.; Kumar Avugadda, S.; Nucci, G.; Nitte, S.; D’Amone, E.; Onesto, V.; Gigli, G.; del Mercato, L.L.; Pellegrino, T. Co-loading of Doxorubicin and Iron Oxide Nanocubes in Polycaprolactone Fibers for Combining Magneto-Thermal and Chemotherapeutic Effects on Cancer Cells. Journal of Colloid And Interface Science, 2022, 607, 34-44.


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