Conjugated Polymers Based Platform and Keratinocytes: a Friendship Tale
Anthea Villano a b, Paola Lagonegro b, Elena Mancinelli b, Vanessa Spagnolo b, Maria Rosa Antognazza b
a Department of Physics, Politecnico di Milano, Milan (Italy)
b Center for Nano Science and Technology, Istituto Italiano di Tecnologia, 20134 Milan (Italy)
Proceedings of Bioelectronic Interfaces: Materials, Devices and Applications (CyBioEl)
Limassol, Cyprus, 2024 October 22nd - 25th
Organizers: Eleni Stavrinidou and Achilleas Savva
Oral, Anthea Villano, presentation 034
Publication date: 28th June 2024

The skin is the largest organ in the human body and consists of several layers, the outermost of which is the epidermis. Keratinocytes, the predominant cell type in the epidermis, are essential for maintaining skin integrity and barrier function. During wound healing, the dynamic process of proliferation, differentiation and apoptosis of keratinocytes, which are typically involved in the continuous renewal of the epidermis, is accelerated [1].

These processes can be further modulated by nanostructured devices based on conjugated polymers and sensible to the green light to facilitate re-epithelialization of the wound site. Active interfaces with nanoscale components are particularly useful for interfacing and adapting to the complex nanoscale structural features of living tissues. Conjugated polymers are emerging as optimal candidates for interacting with living organisms due to their high biocompatibility and ability to combine the chemical and mechanical advantages of organic materials with the unique optoelectronic properties of semiconductors. Poly(3-hexylthiophene-2,5-diyl) (P3HT) is the chosen organic and photoelectrochemically active conjugated polymer. As a semiconductor, P3HT modulates the cell membrane potential through its interaction with cells, absorbing light in the visible spectrum and supporting charge photogeneration, which sustains both electronic and ionic charge transport [2].

In this work we report the synthesis and optoelectronic and morphological characterization of biocompatible and photosensitive platform capable of modulating the epithelial cells physiology. P3HT-based devices have the potential to open new frontiers in regenerative medicine, with significant implications for therapeutic strategies in the treatment of skin injuries and chronic wounds.

We use our own and third party cookies for analysing and measuring usage of our website to improve our services. If you continue browsing, we consider accepting its use. You can check our Cookies Policy in which you will also find how to configure your web browser for the use of cookies. More info