Dual-Mode Biosensing: Comparing SPR and OFET for Advanced Surface Modification Analysis
Annalisa Bonfiglio a, Andrea Spanu a, Davood Hatami b, J. Dostalek c d, R. Hasler c, W. Knoll c, S. Szunerits e
a Scuola Universitaria Superiore IUSS, Piazza della Vittoria 15, 27100 - Pavia, Italy
b Dipartimento di Ingegneria Elettrica ed Elettronica, Università di Cagliari, Piazza d'Armi, 09123 - Cagliari, Italy
c Laboratory for Life Sciences and Technology (LiST), Faculty of Medicine and Dentistry, Danube Private University, Krems 3500, Austria
d FZU-Institute of Physics, Czech Academy of Sciences, Prague 182 21, Czech Republic
e Institut d'Electronique, de Microélectronique et de Nanotechnologie (IEMN) UMR CNRS 8520, Université de Lille - Faculté des Sciences et Technologies 50, avenue de Halley, 59658 Villeneuve d'Ascq, France
Proceedings of Bioelectronic Interfaces: Materials, Devices and Applications (CyBioEl)
Limassol, Cyprus, 2024 October 22nd - 25th
Organizers: Eleni Stavrinidou and Achilleas Savva
Invited Speaker, Annalisa Bonfiglio, presentation 038
Publication date: 28th June 2024

Introducing an innovative monitoring system designed to evaluate surface modification by thin molecular layers, this technology integrates Surface Plasmon Resonance (SPR) with electronic detection via Organic Field-Effect Transistor (OFET) technology. Central to the system is an Extended Gate OTFT (EG-OTFT) configuration that includes a nanostructured component for surface plasmon resonant excitation. This unique device structure not only reliably detects layer-by-layer deposition of various polymers, akin to traditional SPR, but also uniquely discerns between positively and negatively charged layers due to the EG-OTFT's detection capabilities. This dual functionality significantly enhances the system's bioanalytic measurement potential. The combination of optical and electronic detection offers versatility and heightened sensitivity, marking a substantial advancement in biosensing technology. This system provides a cost-effective, reliable, and detailed analysis of surface modifications, crucial for diverse scientific and industrial applications, from biomedical diagnostics to environmental monitoring. This development ushers in more accessible and efficient monitoring platforms tailored to the evolving demands of modern research and applications.

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