Automated Electrode Functionalization for Protein Detection with Organic Electrochemical Transistors
Raphaela Silva a, Atheer Alqatari a, Adel Hama a, Tianrui Chang a, Luca Salvigni a, Stefan T. Arold a, Raik Grünberg a, Sahika Inal a
a King Abdullah University of Science and Technology (KAUST), Saudi Arabia
Proceedings of Bioelectronic Interfaces: Materials, Devices and Applications (CyBioEl)
Limassol, Cyprus, 2024 October 22nd - 25th
Organizers: Eleni Stavrinidou and Achilleas Savva
Poster, Raphaela Silva, 049
Publication date: 28th June 2024

Organic electrochemical transistors (OECTs) have emerged as a promising tool for electrochemical biosensors, allowing both the transduction and amplification of biochemical signals. The application of OECTs for protein sensing typically requires the modification of the gate electrode surface with a biorecognition unit, a time-consuming process that requires manual sample preparation, thus limiting the scalability of this platform. Ultimately, one of the goals in biosensor development is to come up with scalable, high-throughput systems that enable large-scale studies, providing comprehensive data for protocol validation, while facilitating more efficient and reliable analysis. In this work we utilize a liquid handling robot designed to process up to 96 electrodes simultaneously, significantly enhancing the efficiency and reproducibility of electrode preparation. Subsequent OECT measurements are integrated into the workflow, allowing for rapid and automated data acquisition. This approach not only reduces labor-intensive processes but also accelerates the design and validation of protocols for translational research.

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