In situ synthesised conductive polymers on native lipid bilayers
Diana Priyadarshini a
a Laboratory of Organic Electronics, Department of Science and Technology, Linköping University, Norrköping SE-60174, Sweden
Proceedings of Bioelectronic Interfaces: Materials, Devices and Applications (CyBioEl)
Limassol, Cyprus, 2024 October 22nd - 25th
Organizers: Eleni Stavrinidou and Achilleas Savva
Poster, Diana Priyadarshini, 051
Publication date: 28th June 2024

Seamless integration between biological systems and electrical components is essential for enabling a twinned biochemical-electrical recording and therapy approach to understand and combat neurological disorders. Employing bioelectronic systems made up of conjugated polymers, which have an innate ability to transport both electronic and ionic charges, provides the possibility of such integration. Translating enzymatically polymerised conductive wires, recently demonstrated in plants and simple organism systems, into mammalian models, is of particular interest for the development of next-generation devices that could monitor and modulate neural signals. As a first step toward achieving this goal, enzyme-mediated polymerisation of two thiophene-based monomers was already demonstrated on a synthetic lipid bilayer supported on a Au surface. This study is extended to supported lipid bilayers made up of native lipids derived from cell membranes as the next step in implementing this system in vivo, and to gain further insights into the molecular interactions occuring at the polymer-bilayer interface.

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