The synthesis of colloidal quantum dots (QDs) has attracted considerable interest in recent decades due to their exceptional photoluminescence properties, which open the way for many applications including light-emitting diodes, solar concentrators, and luminescent probes for bio-imaging and biosensors. To improve the reproducibility and scale up the production, continuous flow synthesis has recently emerged as a promising approach for the precision synthesis of high-quality QDs. Compared to batch synthesis, this method offers a better control of the reaction conditions (e.g., heating rate, reaction time and pressure) thanks to the improved heat and mass transfer in small-diameter tubular reactors, and enables faster, automated reactions. The approach is highly versatile, and we applied it for the synthesis of QDs from a variety of materials in both aqueous and organic media. However, the adoption of continuous flow synthesis to new materials is still challenging due to the specific requirements of this technique, such as the absence of solid or gaseous by-products, the solubility of the precursors at room temperature and the low viscosity of the reaction mixture. Consequently, transferring established reaction conditions from batch to flow synthesis is not straightforward and requires specific development phases upstream. We will demonstrate these steps with two representative examples: the continuous flow synthesis of highly luminescent PbS/CdS and InP/ZnS core/shell QDs.The synthesis of colloidal quantum dots (QDs) has attracted considerable interest in recent decades due to their exceptional photoluminescence properties, which open the way for many applications including light-emitting diodes, solar concentrators, and luminescent probes for bio-imaging and biosensors. To improve the reproducibility and scale up the production, continuous flow synthesis has recently emerged as a promising approach for the precision synthesis of high-quality QDs. Compared to batch synthesis, this method offers a better control of the reaction conditions (e.g., heating rate, reaction time and pressure) thanks to the improved heat and mass transfer in small-diameter tubular reactors, and enables faster, automated reactions. The approach is highly versatile, and we applied it for the synthesis of QDs from a variety of materials in both aqueous and organic media. However, the adoption of continuous flow synthesis to new materials is still challenging due to the specific requirements of this technique, such as the absence of solid or gaseous by-products, the solubility of the precursors at room temperature and the low viscosity of the reaction mixture. Consequently, transferring established reaction conditions from batch to flow synthesis is not straightforward and requires specific development phases upstream. We will demonstrate these steps with two representative examples: the continuous flow synthesis of highly luminescent PbS/CdS[1] and InP/ZnS [2] core/shell QDs.