From One- to Three-Photon Fluorescence Nanothermometry, Hyperthermia, and Imaging based on Lanthanide doped Nanomaterials.
Carlos Jacinto a
a Grupo de Fotônica e Fluidos Complexos, Instituto de Física, Universidade Federal de Alagoas, Maceió-AL
Invited Speaker, Carlos Jacinto, presentation 003
Publication date: 10th April 2014
Over the last few years, the scientific community has invested a lot of effort to develop highly sensitive fluorescence nanomaterials for the most diverse applications such as nanothermometry, bio-imaging, display, biolable, etc [1-10]. It is known that cellular events are marked basically by changes in temperature and also that two photon fluorescence nanothermometer (FNThM) has been indicated as a more efficient system for highly penetrating fluorescence bio-imaging in comparison to one photon system [1-3]. But, is this a law? Not, we demonstrate that the emission by one photon could present better deep-penetration [10,11]. In fact, thermal sensing at the micro- and nano-scales are required for high spatial resolution of temperature gradients and is an indispensible tool for dynamical studies of diverse small systems including electrical, magnetic, photonic, and biological ones [7-9,12]. In these “nanothermometers”, the thermal sensing method relies upon the particular parameter that displays a temperature dependence, which gives rise to high resolution thermal imaging techniques, such as thermal coupled levels, spectral shift, polarization, etc. Indeed luminescent nanoparticles have become an important tool mainly in medical applications because of its ability to detection and treatment of human diseases, especially for cancers. Because of the, in general, nonhomogenous distribution of concentration, the best system is that one presenting independence on the concentration. In the present talk, we preset a review of the recent results about one-, two, and three-photon lanthanide doped fluorescence nanothermometry. The potential of the investigated system for bioimaging and hyperthermia are also discussed.

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