DOI: https://doi.org/10.29363/nanoge.nias.2021.004
Publication date: 13th September 2021
Advanced optoelectronic systems that can intimately integrate with the brain and the peripheral nervous system have the potential to accelerate progress in neuroscience research and to enable new approaches in patient care. Specifically, capabilities for injecting electronics, light sources, photodetectors, multiplexed sensors, programmable microfluidic networks and other components into precise locations of the deep brain and for softly laminating them onto targeted regions of the surfaces of the brain or the peripheral nerves will create unique and important opportunities in stimulation, inhibition and real-time monitoring of neural circuits. In this talk, we will describe foundational concepts in materials science and assembly processes for these types of technologies, in 1D, 2D and 3D architectures. Examples in system level demonstrations include ‘cellular-scale’, injectable optofluidic neural probes for behavioral research on animal models, 3D mesoscale networks for study of neural signal propagation in organoids, and closed-loop, wireless systems for optogenetic control of bladder function.
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