Operation mechanism of n-type organic electronic metabolite sensors
Victor Druet a, Prem Nayak a, David Ohayon a, Anil Koklu a, Sahika Inal a, Xingxing Chen b, Maximilian Moser c, Iain McCulloch b c
a King Abdullah University of Science and Technology (KAUST), Biological and Environmental Science and Engineering (BESE) Division, Thuwal 23955-6900, Saudi Arabia
b King Abdullah University of Science and Technology, Physical Sciences and Engineering Division, KAUST Solar Center, 23955, Thuwal, Saudi Arabia
c Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA
Materials for Sustainable Development Conference (MATSUS)
Proceedings of nanoGe Spring Meeting 2022 (NSM22)
#OMIECs22. Organic mixed-ionic-electronic conductors and their application in Emerging Technologies
Online, Spain, 2022 March 7th - 11th
Organizers: Aristide Gumyusenge and Alexander Giovannitti
Contributed talk, Victor Druet, presentation 314
DOI: https://doi.org/10.29363/nanoge.nsm.2022.314
Publication date: 7th February 2022

When combined with oxidase enzymes, the NDI-T2 based electron transporting (n-type) polymer led to high performance metabolite sensors, yet their working mechanism has been poorly understood.[1], [2] By monitoring oxygen, hydrogen peroxide, and pH changes in the electrolyte surrounding the n-type channel and gate as well as the potential of each electrical contact in the transistor, we shed light on the catalytic events occurring at the polymer-enzyme interface. We show that in its doped sate, the n-type film performs oxygen reduction reaction and that the n-OECT characteristics are sensitive to oxygen. We find a correlation between the amount of dissolved oxygen and the n-OECT sensor current generated during the metabolite oxidation and that using the n-type polymer at the gate electrode is critical for sensor operation. Our results show the importance of in operando analysis for understanding polymer-catalytic enzyme activity, as well as the importance of ambient oxygen in the operation of n-type devices.

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