Halide perovskite nanoparticles have revolutionized the development of optoelectronic devices due to their exceptional photophysical properties. Recently, incorporating chirality into these nanoarchitectures has opened unprecedented horizons by leveraging quantum-level spin control. This breakthrough enables advanced applications, such as the direct emission of circularly polarized light (CPL) in light-emitting diodes (LEDs). However, transitioning these technologies toward a pre-industrial scale demands a rigorous evaluation of their environmental and economic viability under strict sustainability criteria.

This work presents results on the environmental impacts, costs, and toxicity profiles of nanoparticles synthesized through novel procedures designed to improve sustainability within the Safe and Sustainable by Design framework. Building upon this, preliminary sustainability findings for chiral perovskite nanoparticles synthesis are showcased. In other sectors, particularly pharmaceuticals, agrochemicals, and polymers, significant differences have been documented regarding the environmental impacts associated with chiral versus non-chiral materials. Many chiral pesticides and drugs exhibit distinct levels of ecotoxicity and environmental persistence depending on their enantiopurity. Consequently, manufacturing and utilizing a racemate may underestimate or overestimate environmental risks compared to its enantiopure counterpart. Therefore, a fundamental focus of this study is the development of new hazard characterization factors capable of differentiating toxicity profiles between enantiomers, addressing a critical data gap in conventional evaluation platforms.

Furthermore, synthesis and separation processes for chiral compounds to obtain pure enantiomers require additional steps or specialized reagents, which inherently increases their energy and carbon footprints compared to equivalent non-chiral materials. Nevertheless, our findings indicate that this increase is strategically offset by the superior performance of the resulting optoelectronic devices. Notably, direct CPL emission eliminates the need for traditional external optical filters, which typically trap and waste over 50% of light efficiency, thereby optimizing the overall energy performance of the system.

Finally, we introduce a novel methodological approach to analyze the criticality of the specific materials used in these chiral optical devices and compared to conventional ones. This analysis provides an integrated assessment of supply chain vulnerability.

Ultimately, this study defines a holistic matrix that inextricably links advanced device performance with the economic and ecological sustainability of the material cycle.